Composition:

Each Ambezim-G film coated tablet contains:
Trypsin 5 mg. 

Chymotrypsin 5 mg (Equivalent to 200,000 proteolytic Units).

Pharmacodynamics:

Ambezim-G contains trypsin & chymotrypsin, pancreatic enzymes, which are administered in a form & dosage that favors an adequate absorption from the intestinal tract.

Ambezim-G reduces the intensity of inflammation, attenuates the pain, helps in the resolution of oedema & exudate & favors the penetration of antibacterial agents in the affected areas.

Ambezim-G is therefore useful in infective & traumatic conditions accompanied by a local inflammatory reaction where it will accelerate recovery & limit fibrosis & adhesions.

Trypsin & chymotrypsin is a widely used oral proteolytic enzyme combination to hasten repair of traumatic, surgical, and orthopedic injuries. 

It shows high bioavailability without losing its biological activities as an anti-inflammatory, anti-edematous, fibrinolytic, antioxidant, and anti-infective agent.

These properties help in resolving signs and symptoms of inflammation due to tissue injury and facilitate the repair process. It also demonstrates analgesic effects and reduces the pain associated with healing.

Pharmacokinetics:

Trypsin & chymotrypsin are absorbed after oral dosage administration.

They are formulated as enteric coated tablets to resist gastric juice but dissolve in the higher pH of the small intestine & release the dose of enzyme at this point.

Therapeutic Indications:

Resorption of post-traumatic & post-operative oedema & exudate.

Adjunctive therapy in localized inflammatory conditions such as:

phlebitis, thrombophlebitis, decubitus ulcers.

(ENT):
Sinusitis, Otitis, prevention of post-operative adhesions.

(Ophthalmology)
Ocular trauma & hemorrhage.

(Gynecology)
Episiotomy, perennial lacerations following delivery.
Exudative conditions of the female genital organs with a tendency to fibrosis & adhesions.

(Pneumology)

Broncho-pulmonary inflammation and tracheal-bronchitis.

(Stomatology)

Teeth extractions, periodontium / gum inflammations and stomatological / maxillofacial surgery.

Dosage and Administration:

The average dose is two tablets to be taken up to four times daily as follows: two tablets to be taken one hour before each of the three meals & two tablets to be taken just before going to bed. In particular serious clinical conditions, dosage can be increased according to the judgment of the physician.

N.B: Dosage must be established individually according to the need & to the case.

Dosage must be reduced proportionately for children according to age, weight & following medical advice.

Drug-Drug Interactions:

Anticoagulants: Avoid when taken concomitantly with Ambezim-G.

Precautions:

Appropriate antibacterial therapy must be administered in cases of bacterial infections. 

Pregnancy: safe use of proteolytic enzymes have not been established yet.

Proteolytic enzymes accelerate the dissolution of surgical sutures made of material from animal origin.

Contraindications:

Known hypersensitivity reactions to trypsin & chymotrypsin. Severe general & local infections (tuberculosis, septicemia, etc.) Peptic ulcer, Severe hepatic or renal disease. Disorders of the blood clotting mechanism & Hemorrhagic diathesis.

Adverse Reactions:

Due to their protein nature, proteolytic enzymes can cause allergic reactions or anaphylactic shock which if they occur, should be treated as usual rarely.

Serious manifestations can follow oral administration of the product.

Other adverse reactions can occur, such as: nausea, vomiting, diarrhea, albuminuria, hematuria & Hemorrhagic diathesis.

Patient Instructions:

Ambezim-G enteric coated tablet should be taken one hour before each of the three meals.

Presentation and Storage:

Ambezim-G Available in a pack of 3 Strips each one is of 10 tablets.

Store in a dry place at temperature not exceed 30 C